Prerequisites: Biol Chem 515 or equivalent, EHS 511
Description: The objective of this course is to provide an in-depth analysis of the biochemical and molecular pathways altered in cells and organisms through exposure to environmental and therapeutic chemicals. The content is directed toward the needs of doctoral and masters students in the basic biomedical sciences involved in laboratory research projects. Topics will cover areas of modern research emphasis and focus on how chemicals act to disturb cellular processes through interaction with cellular receptors, ion channels, transporters, signal transduction pathways, transcription factors, metabolic pathways, enzymes, cytoskeletal elements and other macromolecular targets. Specific information about the latest theories on the regulation and initiation of cell death, mediation of toxicity through hredox status and oxidative stress, mechanisms of carcinogenesis, genoxicity and immunotoxicology will also be discussed.