Description: EHS 674 uses a hands-on approach to experiment and interpret modeling techniques applied to environmental health assessment. It first addresses steady-state multi-media modeling, exposure modeling, dermal uptake and pharmacokinetic modeling. It then expands the theory to dynamic modeling and Monte-Carlo approaches applied to probalistic risk assessment.
Course Goals: 1.To understand and apply multimedia models of fate and exposure as well as diagnostic tools to predict masses of contaminants in the environment, in order to evaluate the resulting exposures, impacts, and human health risks.
2.To apply and interpret Pharmacologically Based PharmacoKinetic (PBPK) models for risk assessment.
3.To test methods for the assessment of bacterial risks and the propagation of antibiotic resistance.
4.To introduce dynamic modeling, Monte Carlo simulations for probabilistic risk and uncertainty propagation in models.
Competencies: 1. To be able to use and interpret a parsimonious multi-media model and apply it to case studies.
2. To be able to assess dynamic behaviors in the environment and in humans, using PBPK models.
3. To be able to understand and critique modeling studies, including model evaluation and sensitivity and uncertainty analyses.
4. To be able to assess the development of antibiotic resistance.