Prerequisites: Physiology and EHS 511 or equivalent.
Description: This course will provide and introduction to the histologic damage produced by chemical toxicants. A combination of lectures, student-led discussions and slide-reading sessions will be used to integrate concepts of toxicological mechanism, physiology and pathologic outcome. Emphasis will be place on molecular methods and mechanisms used for the diagnosis and investigative toxicological pathology. The pathology associated with chemicals that damage the major organ systems of humans and mammals will be discussed. During the two credit hours of didactic class presentations student will lead discussions on the pathologic effects of chemicals on cells, tissues and organs and the pathophysiologic outcome. This course is intended for advanced graduate students in the life sciences.
Description: This laboratory course will provide an introduction to the histopathology associated with chemical exposures. Students will perform routine histological maneuvers on tissues from rats treated with “unknown” chemicals. Following microscopic inspection of tissues, students will describe the pathological process produced in each tissue and will identify the class of (or specific) chemical to which the organism was exposed.