Ph.D. Student Profile

Khalil  Chedid

Khalil Chedid, M.P.H., M.D., B.S.

  • Doctoral Student

Education

M.P.H., Hospital and Molecular Epidemiology, University of Michigan (2016)
M.D. Wayne State University (2012)
B.S., Biology, University of Michigan (2006)

Research Interests & Projects

My current work explores the risk factors for and outcomes of co-infection with two types of antibiotic resistant bacteria, methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). In rare cases, the antibiotic resistance genes carried by VRE can be transferred to MRSA when they coexist in the same host, resulting in a pathogen with reduced treatment options. Risk factors may also be targets for intervention prior to infection making their identification significant. Furthermore, the research includes molecular analysis of clinical samples to detect any strains of MRSA or VRE which may be hyper-susceptible to co-infection.

I am also developing a project to find an alternative to the current methods of VRE colonization screening. If successful, the new method can be applied in VRE research in the community setting as the current screening methods are impractical for studies outside of healthcare facilities. I would like to use the method to investigate transmission of VRE in the community, both person-to-person and environmental.

Selected Publications

Waack, U., Johnson, T.L., Chedid, K., XI, C., Simmons, L.A., Mobley, H.L.T. Sandkvist, M. Targeting the Type II Secretion System: Development, Optimization, and Validation of a High-Throughput Screen for the Identification of Small Molecule Inhibitors. Frontiers in Cellular and Infection Microbiology. 2017;7. doi:10.3389/fcimb.2017.00380.

Hong, X., Chedid, K., Kalkanis, S.N. Glioblastoma cell line-derived spheres in serum-containing medium versus serum-free medium: A comparison of cancer stem cell properties. International Journal of Oncology. 2012;41(5):1693-1700. doi:10.3892/ijo.2012.1592.