Studies of cancer epidemiology have traditionally been conducted in individual anatomic sites within which the primary tumor developed. On the basis of decades of research in this manner the authors now have extensive knowledge of the risk factors that predispose individuals to specific tumor types such as, for example, breast cancer. However, in recent years, especially as knowledge about molecular profiling of tumors has developed, epidemiologists have focused attention increasingly on the extent to which subtypes of these site-specific cancers possess distinct etiologies. This presentation will describe recent research from the group to create a framework for investigating etiologic heterogeneity in general, and in particular to identify disease sub-types that are the most clearly etiologically distinct when multivariate, possibly high dimensional information is available to characterize the tumors. Light refreshments for seminar guests will be served at 3:00 p.m. in 3755
Department of BiotsatisticsMethods for Identifying Etiologically
Colin Begg, Ph.D., Chairman, Attending Biostatistician - Memorial Sloan Kettering Cancer Center
September 6, 2018
3:15 pm - 5:00 pm
3755 SPH I
1415 Washington Heights
Ann Arbor, MI 48109-2029
Sponsored by: Department of Biotsatistics
Contact Information: Zhenke Wu (zhenkewu@umich.edu) & Peisong Han (peisong@umich.edu)
Studies of cancer epidemiology have traditionally been conducted in individual anatomic sites within which the primary tumor developed. On the basis of decades of research in this manner the authors now have extensive knowledge of the risk factors that predispose individuals to specific tumor types such as, for example, breast cancer. However, in recent years, especially as knowledge about molecular profiling of tumors has developed, epidemiologists have focused attention increasingly on the extent to which subtypes of these site-specific cancers possess distinct etiologies. This presentation will describe recent research from the group to create a framework for investigating etiologic heterogeneity in general, and in particular to identify disease sub-types that are the most clearly etiologically distinct when multivariate, possibly high dimensional information is available to characterize the tumors. Light refreshments for seminar guests will be served at 3:00 p.m. in 3755