Evolution and Transmission of Influenza Virus in Natural Human Infection

MHome is an NIH funded, case ascertained household study of respiratory virus transmission conducted in partnership with Dr. Adam Lauring. Initially developed to evaluate the within- and between-host dynamics of influenza viruses, we have broadened the scope to include SARS-CoV-2 and respiratory syncytial virus (RSV). We identify index cases who test positive for influenza virus, SARS-CoV-2, or RSV and then enroll them and their households. Household members provide serial nasal swabs and complete surveys over a two week period. These data are used to define within-host viral dynamics and viral and host factors associated with transmission.