Faculty Profile

Michael  Boehnke, PhD

Michael Boehnke, PhD

  • Richard G. Cornell Distinguished University Professor of Biostatistics
  • Director, Center for Statistical Genetics
  • Director, Genome Science Training Program
  • M4108 SPH II
  • 1415 Washington Heights
  • Ann Arbor, Michigan 48109-2029

Michael Boehnke is the Richard G. Cornell Distinguished University Professor of Biostatistics. He is Director of the University of Michigan Center for Statistical Genetics and Genome Science Training Program, a member of the National Academy of Medicine, and a Fellow of the American Statistical Association and of the American Association for the Advancement of Science. Dr. Boehnke did his undergraduate degree in Mathematics at the University of Oregon and his PhD in Biomathematics at UCLA. He has been on the faculty at Michigan since 1984. Dr. Boehnke's research focuses on problems of study design and statistical analysis of human genetic data with a particular emphasis on development and application of statistical methods for human gene mapping, with a current focus on disease and trait association studies based on genome sequence and genotype-array data. He is a principal investigator of the Finland-United States Investigation of NIDDM (FUSION) study of the genetics of type 2 diabetes and the InPSYght sequencing study of bipolar disorder and schizophrenia. He is a founder and steering committee member of the DIAGRAM (type 2 diabetes), DIAMANTE (type 2 diabetes), MAGIC (glucose and insulin traits), GIANT (anthropometric traits), and Global Lipids genome-wide association meta-analysis consortia. Dr. Boehnke has >370 refereed publications and has chaired or co-chaired 21 doctoral committees and supervised 10 post-doctoral fellows; 26 of his 31 completed trainees went directly to faculty positions at major research universities.

  • PhD, Biomathematics, UCLA, 1983
  • B.A., Mathematics, University of Oregon, 1977

  • Design and Analysis of Human Gene Mapping Studies
  • Identifying Genes for Type 2 Diabetes: FUSION
  • Identifying T2D Variants by DNA Sequencing in Multiethnic Samples
  • Whole Genome Sequencing for Schizophrenia and Bipolar Disorder in the GPC
  • Accelerating Medicines Partnership: Enhancement of the Type 2 Diabetes Knowledge Portal

  • Zhang F, Flickinger M, Taliun SAG; InPSYght Psychiatric Genetics Consortium, Abecasis GR, Scott LJ, McCaroll SA, Pato CN, Boehnke M, and Kang HM (2020) Ancestry-agnostic estimation of DNA sample contamination from sequence reads. Genome Research doi: 10.1101/gr.246934. PMID: 31980570.
  • Locke AE, Steinberg KM, Chiang CWK, Service SK, Havulinna AS, Stell L, Pirinen M, Abel HJ, Chiang CC, Fulton RS, Jackson AU, Kang CJ, Kanchi KL, Koboldt DC, Larson DE, Nelson J, Nicholas TJ, Pietilä A, Ramensky V, Ray D, Scott LJ, Stringham HM, Vangipurapu J, Welch R, Yajnik P, Yin X, Eriksson JG, Ala-Korpela M, Järvelin MR, Männikkö M, Laivuori H; FinnGen Project, Dutcher SK, Stitziel NO, Wilson RK, Hall IM, Sabatti C, Palotie A, Salomaa V, Laakso M, Ripatti S, Boehnke M, and Freimer NB (2019) Exome sequencing of Finnish isolates enhances rare-variant association power. Nature 572:323-328. PMCID: PMC6697530.
  • Flannick J, Mercader JM, Fuchsberger C, Udler MS, Mahajan A, Wessel J, Teslovich TM, Caulkins L, Koesterer R, Barajas-Olmos F, Blackwell TW, Boerwinkle E, Brody JA, Centeno-Cruz F, Chen L, Chen S, Contreras-Cubas C, Córdova E, Correa A, Cortes M, DeFronzo RA, Dolan L, Drews KL, Elliott A, Floyd JS, Gabriel S, Garay-Sevilla ME, García-Ortiz H, Gross M, Han S, Heard-Costa NL, Jackson AU, Jørgensen ME, Kang HM, Kelsey M, Kim B-J, Koistinen HA, Kuusisto J, Leader JB, Linneberg A, Liu C-T, Liu J, Lyssenko V, Manning AK, Marcketta A, Malacara-Hernandez JM, Matsuo K, Mayer-Davis E, Mendoza-Caamal E, Mohlke KL, Morrison AC, Ndungu A, Ng MCY, O'Dushlaine C, Payne AJ, Pihoker C, Broad Genetics Platform, Post WS, Preuss M, Psaty BM, Vasan RS, Bayner NW, Reiner AP, Revilla-Monsalve C, Robertson NR, Santoro N, Schurmann C, So WY, Soberón X, Stringham HM, Strom TM, Tam CHT, Thameem F, Tomlinson B, Torres JM, Tracy RP, van Dam RM, Vujkovic M, Wang S, Welch RP, Witte DR, Wong T-Y, Atzmon G, Barzilai N, Blangero J, Bonnycastle LL, Bowden DW, Chambers JC, Chan E, Cheng C-Y, Cho YS, Collins FS, de Vries PS, Duggirala R, Glaser B, Gonzalez C, Gonzalez ME, Groop L, Kooner JS, Kwak SH, Laakso M, Lehmann DM, Nilsson P, Spector TD, Tai ES, Tuomi T, Tuomilehto J, Wilson JG, Aguilar-Salinas CA, Bottinger E, Burke B, Carey DJ, Chan J, Dupuis J, Frossard P, Hedckbert S, Hwang MY, Kim YJ, Kirchner HL, Lee J-Y, Lee J, Loos R, Ma RCW, Morris AD, O'Donnell CJ, Palmer CAN, Pankow J, Park KS, Rasheed A, Saleheen D, Sim X, Small KS, Teo YY, Haiman C, Hanis CL, Henderson BE, Orozco L, Tusié-Luna T, Dewey FE, Baras A, Gieger C, Meitinger T, Strauch K. Lange L, Grarup N, Hansen T, Pedersen O, Zeitler P, Dabelea D, Abecasis G, Bell GI, Cox NJ, Seielstad M, Sladek R, Meigs JB, Rich S, Rotter JI, DiscovEHR Collaboration, CHARGE, LuCamp, ProDiGY, GoT2D, ESP, SIGMA-T2D, T2D-GENES, AMP-T2D-GENES, Altshuler D, Burtt NP, Scott LJ, Morris AP, Florez JC, McCarthy MI, and Boehnke M (2019) Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. Nature 570:71-76. PMCID: PMC6699738.
  • Shi J, Boehnke M, and Lee S (2019) Trans-ethnic meta-analysis of rare variants in sequencing association studies. Biostatistics Dec 28. pii: kxz061. PMID: 31883325.
  • Quick C, Fuchsberger C, Taliun D, Abecasis G, Boehnke M, and Kang HM (2018) emeraLD: rapid linkage disequilibrium estimation with massive datasets. Bioinformatics 35:164-166. PMCID: PMC6298049.
  • Latva-Rasku A, Honka M-J, Stančáková A, Koistinen HA, Kuusisto J, Guan Li, Manning AK, Stringham H, Gloyn AL, Lindgren CM, T2D-GENES Consortium, Collins FS, Mohlke KL, Scott LJ, Karjalainen T, Nummenmaa L, Boehnke M, Nuutila P, and Laakso M (2018) A partial loss-of-function variant in AKT2 is associated with reduced insulin-mediated glucose uptake in multiple insulin sensitive tissues: a genotype-based callback positron emission tomography study. Diabetes 67:334-342. PMCID: PMC5780065.
  • Mahajan A, Taliun D, Thurner M, Robertson NR, Torres JM, Rayner NW, Payne AJ, Steinthorsdottir V, Scott RA, Grarup N, Cook JP, Schmidt EM, …, Abecasis GR, Meigs JB, Rotter JI, Marchini J, Pedersen O, Hansen T, Langenberg C, Wareham NJ, Stefansson K, Gloyn AL, Morris AP, Boehnke M, and McCarthy MI (2018) Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nature Genetics doi: 10.1038/s41588-018-0241-6. PMID: 30297969.
  • Ray D and Boehnke M (2017) Methods for meta-analysis of multiple traits using GWAS summary statistics. Genetic Epidemiology 42:134-145.
  • Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, Ma C, Fontanillas P, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, …, Abecasis G, Florez JC, Scott LJ, Morris AP, Kang HM, Boehnke M, Altshuer D, and McCarthy MI (2016) The genetic architecture of type 2 diabetes (2016) Nature 536:41-47.
  • Mohlke KL and Boehnke M (2015) Recent advances in understanding the genetic architecture of type 2 diabetes. Human Molecular Genetics 24:R85-R92.
  • Flickinger M, Jun G, Abecasis GR, Boehnke M, and Kang HM (2015) Correcting for sample contamination in genotype calling of DNA sequence data.  American Journal of Human Genetics 97:284-290.

  • American Society for Human Genetics
  • International Genetic Epidemiology Society