Dr. Justin Colacino is an Assistant Professor of Environmental Health Sciences in the School of Public Health. His research focuses on understanding environmental and dietary factors in carcinogenesis and cancer prevention. Specifically, the goal of his research is to characterize the environmental susceptibility of normal human stem cell populations, elucidating the etiology of sporadic cancers. Of particular interest are understanding the changes that occur at the epigenetic and transcriptional level, changes which affect not only gene expression but also how progenitor cells differentiate and divide. His research group combines wet lab bench work and bioinformatic and statistical analysis of large scale genomic and epidemiologic data sets to translate findings from in vitro models to the population level. Dr. Colacino is an active member of the Society of Toxicology (SOT) and the American Association for Cancer Research (AACR) and serves on the Editorial Review Board of Environmental Epigenetics and the Editorial Board of Cancer Research.
- PhD, Environmental Health Sciences, University of Michigan School of Public Health, 2014
- M.A., Statistics, University of Michigan, 2014
- MPH, , University of Texas School of Public Health at Dallas, 2009
- B.S., Biochemistry, University of Texas at Austin, 2005
- Thong, T, C.A. Forté, E.M. Hill and J.A. Colacino (2019). Environmental exposures, stem cells, and cancer. Pharmacology and Therapeutics. https://doi.org/10.1016/j.pharmthera. 107398.
- Bakulski, K.M., J. Dou, N. Lin, S. London S and J.A. Colacino (2019). DNA methylation signature of smoking in lung cancer is enriched for exposure signatures in newborn and adult blood. Scientific Reports. https://www.nature.com/articles/s41598-019-40963-2
- Gonzalez T., J.M. Rae and J.A. Colacino (2019). Implications of Environmental Estrogens on Breast Cancer Treatment and Progression. Toxicology. https://doi.org/10.1016/j.tox.2019.03.014
- Hill, E.M., R.M. Esper, R.B. Simon, M.N. Aslam, Y. Jiang, M.K. Dame, S.D. McClintock, J.A. Colacino, Z. Djuric, M.S. Wicha, W.L. Smith and D.E. Brenner (2019). . Dietary polyunsaturated fatty acids modulate the adipose secretome to influence mammary stem cell self-renewal. Journal of Nutritional Biochemistry. https://doi.org/10.1016/j.jnutbio.2019.05.007
- NguyenV.K., J.A. Colacino, J. Arnot, J. Kvasnicka and O. Jolliet (2018). Characterization of age-based trends to identify chemical biomarkers of higher levels in children. Environment International. https://doi.org/10.1016/j.envint.2018.10.042
- Rocco S.A., L. Koneva, L.Y.M. Middleton, T. Thong, S. Solanki, S. Karram, K. Nambunmee, C. Harris, L.S. Rozek, M.A. Sartor, Y.M. Shah and J.A. Colacino. Cadmium exposure inhibits branching morphogenesis and causes alterations consistent with HIF-1α inhibition in human primary breast organoids. Toxicological Sciences. https://doi.org/10.1093/toxsci/kfy112
- Colacino J.A., E. Azizi, M.D. Brooks, S. Fouladdel, S. McDermott, M. Lee, D. Hill, M.A. Sartor, L.S. Rozek, Wicha MS. (2018). Heterogeneity of normal human breast stem and progenitor cells as revealed by transcriptional profiling. Stem Cell Reports. doi: https://doi.org/10.1016/j.stemcr.2018.03.001
- Dame M.K, D. Attili, S. McClintock, P.H. Dedhia, P. Ouilette, O. Hardt, A.M. Chin, X. Xue, J. Laliberte, E.K. Katz, G.M. Newsome, D. Hill, A. Miller, D. Agorku, Y.H. Tsai, D. Agorku, C.H. Altheim, A. Bosio, B. Simon, L.C. Samuelson, J.A. Stoerker, H. Appelman, J. Varani, M.S. Wicha, D.E. Brenner, Y.M. Shah, J. Spence and J.A. Colacino (2018). Identification, isolation, and characterization of human LGR5-positive colon adenoma cells. Development. dev.153049
- Wang T., E.C. Pehrsson, D. Purushotham, D. Li, B. Zhang, H.A. Lawson, M.A. Province, C. Krapp, Y. Lan, C. Coarfa, T.A. Katz, W.Y. Tang, Z. Wang, S. Biswal, S. Rajapoalan, J.A. Colacino, M.A. Sartor, K. Neier, D. Dolinoy, J. Pinto, R. Hamanaka, G. Mutlu, H.B. Patisaul, D.L. Aylor, G.E. Crawford, L.H. Chadwick, C.G. Duncan, A.E. Garton and K.A. McAllister (2018). The TaRGET II Consortium, Barolomei MS, Walker CL, Tyson FL. The NIEHS TaRGET II Consortium and Environmental Epigenomics. Nature Biotechnology 36, 225–227 doi:10.1038/nbt.4099
- Colacino, J.A., S.P. Mcdermott, M.A. Sartor, M.S. Wicha, and L.S. Rozek (2916). Transcriptomic profiling of curcumin-treated human breast stem cells identifies a role for stearoyl-coa desaturase in breast cancer prevention. Breast Cancer Research and Treatment, 158(1), 29-41:10.1007/s10549-016-3854-4