Faculty Profile

Lars   Fritsche, PhD

Lars Fritsche, PhD

  • Associate Research Scientist of Biostatistics
  • Department of Biostatistics
    University of Michigan
    1415 Washington Heights
    Ann Arbor MI 48109-2029

Lars Fritsche is Assistant Research Scientist in the Department of Biostatistics working with Dr. Bhramar Mukherjee focussing on analyses that combine genetic information obtained from sequencing and genotyping arrays with extensive phenotypic data collected using electronic health records and other population scale approaches.

  • Dr. rer. nat. (equivalent to PhD; summa cum laude), Human Genetics, University of Regensburg, Germany, 2009
  • Diploma in Biology (equivalent to M.Sc.), Genetics, University of Regensburg, Germany, 2004

  • Zhao Z, Bi W, Zhou W, VandeHaar P, Fritsche LG, & Lee S. (2020). UK Biobank Whole-Exome Sequence Binary Phenome Analysis with Robust Region-Based Rare-Variant Test. Am J Hum Genet, 106(1), 3-12. doi:10.1016/j.ajhg.2019.11.012
  • Beesley LJ, Salvatore M, Fritsche LG, Pandit A, Rao A, Brummett C, Willer CJ, Lisabeth LD, & Mukherjee B. (2020). The emerging landscape of health research based on biobanks linked to electronic health records: Existing resources, statistical challenges, and potential opportunities. Stat Med, 39(6), 773-800. doi:10.1002/sim.8445
  • Zajac GJM, Fritsche LG, Weinstock JS, Dagenais SL, Lyons RH, Brummett CM, & Abecasis GR. (2019). Estimation of DNA contamination and its sources in genotyped samples. Genet Epidemiol, 43(8), 980-995. doi:10.1002/gepi.22257
  • Fritsche LG, Beesley LJ, VandeHaar P, Peng RB, Salvatore M, Zawistowski M, Gagliano Taliun SA, Das S, LeFaive J, Kaleba EO, Klumpner TT, Moser SE, Blanc VM, Brummett CM, Kheterpal S, Abecasis GR, Gruber SB, & Mukherjee B. (2019). Exploring various polygenic risk scores for skin cancer in the phenomes of the Michigan genomics initiative and the UK Biobank with a visual catalog: PRSWeb. PLoS Genet, 15(6), e1008202. doi:10.1371/journal.pgen.1008202
  • Dey R, Nielsen JB, Fritsche LG, Zhou W, Zhu H, Willer CJ, & Lee S. (2019). Robust meta-analysis of biobank-based genome-wide association studies with unbalanced binary phenotypes. Genet Epidemiol, 43(5), 462-476. doi:10.1002/gepi.22197
  • Zhou W, Nielsen JB, Fritsche LG, Dey R, Gabrielsen ME, Wolford BN, LeFaive J, VandeHaar P, Gagliano SA, Gifford A, Bastarache LA, Wei WQ, Denny JC, Lin M, Hveem K, Kang HM, Abecasis GR, Willer CJ, & Lee S. (2018). Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies. Nat Genet, 50(9), 1335-1341. doi:10.1038/s41588-018-0184-y
  • Nielsen JB*, Thorolfsdottir RB*, Fritsche LG*, Zhou W*, Skov MW*, Graham SE*, Herron TJ*, McCarthy S*, Schmidt EM*, Sveinbjornsson G*, Surakka I, Mathis MR, Yamazaki M, Crawford RD, Gabrielsen ME, Skogholt AH, Holmen OL, Lin M, Wolford BN, Dey R, Dalen H, Sulem P, Chung JH, Backman JD, Arnar DO, Thorsteinsdottir U, Baras A, O'Dushlaine C, Holst AG, Wen X, Hornsby W, Dewey FE, Boehnke M, Kheterpal S, Mukherjee B, Lee S, Kang HM, Holm H, Kitzman J, Shavit JA, Jalife J, Brummett CM, Teslovich TM, Carey DJ, Gudbjartsson DF, Stefansson K, Abecasis GR, Hveem K, & Willer CJ. (2018). Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. Nat Genet, 50(9), 1234-1239. doi:10.1038/s41588-018-0171-3
  • Nielsen JB*, Fritsche LG*, Zhou W*, Teslovich TM, Holmen OL, Gustafsson S, Gabrielsen ME, Schmidt EM, Beaumont R, Wolford BN, Lin M, Brummett CM, Preuss MH, Refsgaard L, Bottinger EP, Graham SE, Surakka I, Chu Y, Skogholt AH, Dalen H, Boyle AP, Oral H, Herron TJ, Kitzman J, Jalife J, Svendsen JH, Olesen MS, Njolstad I, Lochen ML, Baras A, Gottesman O, Marcketta A, O'Dushlaine C, Ritchie MD, Wilsgaard T, Loos RJF, Frayling TM, Boehnke M, Ingelsson E, Carey DJ, Dewey FE, Kang HM, Abecasis GR, Hveem K, & Willer CJ. (2018). Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development. Am J Hum Genet, 102(1), 103-115. doi:10.1016/j.ajhg.2017.12.00
  • Fritsche LG, Gruber SB, Wu Z, Schmidt EM, Zawistowski M, Moser SE, Blanc VM, Brummett CM, Kheterpal S, Abecasis GR, & Mukherjee B. (2018). Association of Polygenic Risk Scores for Multiple Cancers in a Phenome-wide Study: Results from The Michigan Genomics Initiative. Am J Hum Genet, 102(6), 1048-1061. doi:10.1016/j.ajhg.2018.04.001
  • Zhou W, Fritsche LG, Das S, Zhang H, Nielsen JB, Holmen OL, Chen J, Lin M, Elvestad MB, Hveem K, Abecasis GR, Kang HM, & Willer CJ. (2017). Improving power of association tests using multiple sets of imputed genotypes from distributed reference panels. Genet Epidemiol, 41(8), 744-755. doi:10.1002/gepi.22067
  • Yang J, Fritsche LG, Zhou X, & Abecasis G. (2017). A Scalable Bayesian Method for Integrating Functional Information in Genome-wide Association Studies. Am J Hum Genet, 101(3), 404-416. doi:10.1016/j.ajhg.2017.08.002
  • Yang B, Zhou W, Jiao J, Nielsen JB, Mathis MR, Heydarpour M, Lettre G, Folkersen L, Prakash S, Schurmann C, Fritsche L, Farnum GA, Lin M, Othman M, Hornsby W, Driscoll A, Levasseur A, Thomas M, Farhat L, Dube MP, Isselbacher EM, Franco-Cereceda A, Guo DC, Bottinger EP, Deeb GM, Booher A, Kheterpal S, Chen YE, Kang HM, Kitzman J, Cordell HJ, Keavney BD, Goodship JA, Ganesh SK, Abecasis G, Eagle KA, Boyle AP, Loos RJF, Eriksson P, Tardif JC, Brummett CM, Milewicz DM, Body SC, & Willer CJ. (2017). Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve. Nat Commun, 8, 15481. doi:10.1038/ncomms15481
  • Ding Y, Liu Y, Yan Q, Fritsche LG, Cook RJ, Clemons T, Ratnapriya R, Klein ML, Abecasis GR, Swaroop A, Chew EY, Weeks DE, & Chen W. (2017). Bivariate Analysis of Age-Related Macular Degeneration Progression Using Genetic Risk Scores. Genetics, 206(1), 119-133. doi:10.1534/genetics.116.19699
  • Fritsche LG*, Igl W*, Bailey JN*, Grassmann F*, Sengupta S*, Bragg-Gresham JL, Burdon KP, Hebbring SJ, Wen C, Gorski M, Kim IK, Cho D, Zack D, Souied E, Scholl HP, Bala E, Lee KE, Hunter DJ, Sardell RJ, Mitchell P, Merriam JE, Cipriani V, Hoffman JD, Schick T, Lechanteur YT, Guymer RH, Johnson MP, Jiang Y, Stanton CM, Buitendijk GH, Zhan X, Kwong AM, Boleda A, Brooks M, Gieser L, Ratnapriya R, Branham KE, Foerster JR, Heckenlively JR, Othman MI, Vote BJ, Liang HH, Souzeau E, McAllister IL, Isaacs T, Hall J, Lake S, Mackey DA, Constable IJ, Craig JE, Kitchner TE, Yang Z, Su Z, Luo H, Chen D, Ouyang H, Flagg K, Lin D, Mao G, Ferreyra H, Stark K, von Strachwitz CN, Wolf A, Brandl C, Rudolph G, Olden M, Morrison MA, Morgan DJ, Schu M, Ahn J, Silvestri G, Tsironi EE, Park KH, Farrer LA, Orlin A, Brucker A, Li M, Curcio CA, Mohand-Said S, Sahel JA, Audo I, Benchaboune M, Cree AJ, Rennie CA, Goverdhan SV, Grunin M, Hagbi-Levi S, Campochiaro P, Katsanis N, Holz FG, Blond F, Blanche H, Deleuze JF, Igo RP, Jr., Truitt B, Peachey NS, Meuer SM, Myers CE, Moore EL, Klein R, Hauser MA, Postel EA, Courtenay MD, Schwartz SG, Kovach JL, Scott WK, Liew G, Tan AG, Gopinath B, Merriam JC, Smith RT, Khan JC, Shahid H, Moore AT, McGrath JA, Laux R, Brantley MA, Jr., Agarwal A, Ersoy L, Caramoy A, Langmann T, Saksens NT, de Jong EK, Hoyng CB, Cain MS, Richardson AJ, Martin TM, Blangero J, Weeks DE, Dhillon B, van Duijn CM, Doheny KF, Romm J, Klaver CC, Hayward C, Gorin MB, Klein ML, Baird PN, den Hollander AI, Fauser S, Yates JR, Allikmets R, Wang JJ, Schaumberg DA, Klein BE, Hagstrom SA, Chowers I, Lotery AJ, Leveillard T, Zhang K, Brilliant MH, Hewitt AW, Swaroop A, Chew EY, Pericak-Vance MA, DeAngelis M, Stambolian D, Haines JL, Iyengar SK, Weber BH, Abecasis GR, & Heid IM. (2016). A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat Genet, 48(2), 134-143. doi:10.1038/ng.344
  • Fritsche LG, Fariss RN, Stambolian D, Abecasis GR, Curcio CA, & Swaroop A. (2014). Age-related macular degeneration: genetics and biology coming together. Annu Rev Genomics Hum Genet, 15, 151-171. doi:10.1146/annurev-genom-090413-025610
  • Porcu E, Sanna S, Fuchsberger C, & Fritsche LG. (2013). Genotype imputation in genome-wide association studies. Curr Protoc Hum Genet, Chapter 1, Unit 1.25. doi:10.1002/0471142905.hg0125s7
  • Fritsche LG*, Chen W*, Schu M*, Yaspan BL*, Yu Y*, Thorleifsson G, Zack DJ, Arakawa S, Cipriani V, Ripke S, Igo RP, Jr., Buitendijk GH, Sim X, Weeks DE, Guymer RH, Merriam JE, Francis PJ, Hannum G, Agarwal A, Armbrecht AM, Audo I, Aung T, Barile GR, Benchaboune M, Bird AC, Bishop PN, Branham KE, Brooks M, Brucker AJ, Cade WH, Cain MS, Campochiaro PA, Chan CC, Cheng CY, Chew EY, Chin KA, Chowers I, Clayton DG, Cojocaru R, Conley YP, Cornes BK, Daly MJ, Dhillon B, Edwards AO, Evangelou E, Fagerness J, Ferreyra HA, Friedman JS, Geirsdottir A, George RJ, Gieger C, Gupta N, Hagstrom SA, Harding SP, Haritoglou C, Heckenlively JR, Holz FG, Hughes G, Ioannidis JP, Ishibashi T, Joseph P, Jun G, Kamatani Y, Katsanis N, C NK, Khan JC, Kim IK, Kiyohara Y, Klein BE, Klein R, Kovach JL, Kozak I, Lee CJ, Lee KE, Lichtner P, Lotery AJ, Meitinger T, Mitchell P, Mohand-Said S, Moore AT, Morgan DJ, Morrison MA, Myers CE, Naj AC, Nakamura Y, Okada Y, Orlin A, Ortube MC, Othman MI, Pappas C, Park KH, Pauer GJ, Peachey NS, Poch O, Priya RR, Reynolds R, Richardson AJ, Ripp R, Rudolph G, Ryu E, Sahel JA, Schaumberg DA, Scholl HP, Schwartz SG, Scott WK, Shahid H, Sigurdsson H, Silvestri G, Sivakumaran TA, Smith RT, Sobrin L, Souied EH, Stambolian DE, Stefansson H, Sturgill-Short GM, Takahashi A, Tosakulwong N, Truitt BJ, Tsironi EE, Uitterlinden AG, van Duijn CM, Vijaya L, Vingerling JR, Vithana EN, Webster AR, Wichmann HE, Winkler TW, Wong TY, Wright AF, Zelenika D, Zhang M, Zhao L, Zhang K, Klein ML, Hageman GS, Lathrop GM, Stefansson K, Allikmets R, Baird PN, Gorin MB, Wang JJ, Klaver CC, Seddon JM, Pericak-Vance MA, Iyengar SK, Yates JR, Swaroop A, Weber BH, Kubo M, Deangelis MM, Leveillard T, Thorsteinsdottir U, Haines JL, Farrer LA, Heid IM, & Abecasis GR. (2013). Seven new loci associated with age-related macular degeneration. Nat Genet, 45(4), 433-439, 439e431-432. doi:10.1038/ng.2578

  • German Society of Human Genetics
  • American Society of Human Genetics