Dr. Jackie Goodrich is a Research Assistant Professor of Environmental Health Sciences at the University of Michigan School of Public Health. Dr. Goodrich completed her undergraduate degree in Cellular and Molecular Biology and her doctoral degree in Toxicology at the University of Michigan. She furthered her training with a postdoctoral fellowship at the University of Michigan focused on epigenetics and environmental epidemiology.
Dr. Goodrich's research interests combine toxicology, epidemiology and epigenomics with the goal of identifying epigenetically labile genomic regions that contribute to environmentally-induced disease susceptibility at various life-stages (in utero, early childhood, and adulthood). Epigenetic modification by environmental factors is emerging as a link between exposures to toxicity and disease outcomes. Dr. Goodrich is assessing the impact of chemical exposures from occupational practices or the environment (e.g., mercury, lead, phthalates) on epigenetic modifications (DNA methylation) in epidemiological cohorts from around the globe using both candidate gene and epigenome-wide approaches. She integrates data on exposures, DNA methylation, and health outcomes to better understand disease risk from exposures at vulnerable life-stages. Dr. Goodrich also studies the impact of environmental exposures, particularly to heavy metals such as lead and mercury, on cardiovascular and metabolic health outcomes. Dr. Goodrich works out of the Environmental Epigenetics and Nutrition lab.
B.S., Cellular and Molecular Biology, University of Michigan, 2007
Research Interests & Projects
Heavy metal toxicology
Developmental origins of health and disease
Goodrich J.M., Reddy P., Naidoo R.N., Asharam K., Batterman S., Dolinoy D.C. 2016. Prenatal exposures and DNA methylation in newborns: A Pilot Study in Durban, South Africa. Environmental Science: Processes and Impacts. 18, 908-917. PMID: 27359112.
Parajuli R.P.†, Goodrich J.M.†, Chou H.N., Gruninger S.E., Dolinoy D.C., Franzblau A., Basu N. 2016. Genetic polymorphisms are associated with hair, blood, and urine mercury levels in the American Dental Association (ADA) Study participants. Environmental Research. 149, 247-258. PMCID: PMC4897752.
Goodrich J.M., Chou H.N., Gruninger S.E., Franzblau A., Basu N. 2016. Exposures of Dental Professionals to Elemental Mercury and Methylmercury. Journal of Exposure Science and Environmental Epidemiology. 26, 78-85. PMCID: PMC4689636.
Goodrich J.M.†, Sánchez B.†, Dolinoy D.C., Zhang Z., Hernández-Ávila M., Hu H., Peterson K.E., Téllez-Rojo M.M. 2015. Quality Control and Statistical Modeling for Environmental Epigenetics: A Study on in Utero Lead Exposure and DNA Methylation at Birth. Epigenetics. 10, 19-30. PMCID: PMC4622744.
Goodrich J.M., Basu N., Franzblau A., Dolinoy D.C. 2013. Mercury biomarkers and DNA methylation among Michigan dental professionals. Environmental and Molecular Mutagenesis 54, 195-203. PMCID: PMC3750961.
Goodrich J.M., Basu N. 2012. Variants of glutathione s-transferase pi 1 exhibit differential enzymatic activity and inhibition by heavy metals. Toxicology In Vitro. 26, 630-635. PMCID: PMC3329562.
Goodrich J.M., Wang Y., Gillespie B., Werner R., Franzblau A., Basu N. 2011. Glutathione enzyme and selenoprotein polymorphisms associate with mercury biomarker levels in Michigan dental professionals. Toxicology and Applied Pharmacology. 257, 301-308. PMCID: PMC3324924.
†Denotes equal contribution.
Association for Clinical and Translational Science (ACTS)
Environmental Mutagenesis and Genomics Society (EMGS)
Society of Toxicology (SOT)