Faculty Profile

Jackie Goodrich

Jackie Goodrich, PhD

  • Research Associate Professor, Environmental Health Sciences
  • Global Public Health Faculty Associate

Dr. Goodrich's research interests combine toxicology, epidemiology and epigenomics with the goal of identifying environmental exposures and their mechanisms that contribute to disease susceptibility at various life-stages (in utero, early childhood, and adulthood). Epigenetic modification by environmental factors is one mechanism that can link exposures to toxicity and disease outcomes. Dr. Goodrich is assessing the impact of exposures from the workplace (e.g. firefighting) or the broader environment (e.g., lead, phthalates, PFAS) on epigenetic modifications (DNA methylation) in epidemiological cohorts from around the globe using both candidate gene and epigenome-wide approaches. She integrates data on exposures, DNA methylation, and health outcomes to better understand disease risk from exposures at vulnerable life-stages. Dr. Goodrich is a co-Leader of the DoGoodS-Pi environmental epigenetics laboratory. She is also co-Leader of the Pan Omics and Data Sciences Core of the Michigan Lifestage Environmental Exposures and Disease (M-LEEaD) Center.

  • PhD, Toxicology, University of Michigan, 2011
  • BS, Cellular and Molecular Biology, University of Michigan, 2007

Research Interests:
Environmental epigenomics/epigenetics, developmental origins of health and disease, maternal and child health, firefighter health, global health

Research Projects:
The overarching hypothesis of my research is that the effects of environmental exposures are traceable at the molecular level, namely as alterations to DNA methylation and gene expression, and that these subtle molecular changes contribute to subclinical health impacts and ultimately disease. I employ a variety of study designs and methodological approaches to investigate this hypothesis for a range of exposures. My current research program centers around this hypothesis with several focus areas:

  1. Toxicants and endogenous exposures (i.e. metabolites) in the gestational environment: I study the impact of prenatal exposures on child health in several birth cohorts (MMIP, ELEMENT, ECHO).
  2. Health outcomes in children and adolescents: I study the longitudinal impact of early life exposures on health and development in participants from the ELEMENT cohort.
  3. Occupational health: I investigate whether epigenetic alterations are indicators of toxicity in firefighters from the national Fire Fighter Cancer Cohort Study.
  4. We also assess the impact of chemicals and other exposures on women's health during pregnancy and peri-menopause in MMIP and ELEMENT.

Rygiel C., Goodrich J.M., Solano-Gonzalez M., Mercado-Garcia A., Hu H., Tellez-Rojo M.M., Peterson K.E., Dolinoy D.C. Prenatal Lead (Pb) Exposure and Peripheral Blood DNA Methylation (5mC) and Hydroxymethylation (5hmC) in Mexican Adolescents from the ELEMENT Birth Cohort. 2021. Environmental Health Perspectives, 129(6):67002. PMCID: PMC8216410.

Goodrich J.M., Dolinoy D.C., Sanchez B.N., Zhang Z., Meeker J., Mercado-Garcia A., Solano-Gonzalez M., Hu H., Tllez-Rojo M.M., Peterson K.E. Adolescent epigenetic profiles and environmental exposures from early life through peri-adolescence. Environmental Epigenetics, 2016. doi 10.1093/eep/dvw018. PMCID: PMC5804533.

Labarre J.L., McCabe C.F., Jones T.R., SongP.X.K., Domino S.E., Treadwell M.C., Dolinoy D.C., Padmanabhan V., Burant C.F., Goodrich J.M. Maternallipidome across pregnancy is associated with the neonatal DNA methylome. Epigenomics. 12(23):2077-2092, 2020. PMCID:PMC7857356.

McCabe C.F., Padmanabhan V., Dolinoy D.C., Domino S.E., Jones T.R., Bakulski K., Goodrich J.M. Maternal Environmental Exposure to Bisphenols and Epigenome-Wide DNA Methylation in Infant Cord Blood. Environmental Epigenetics 6(1):dvaa012, 2020. PMCID: PMC7757124.

Goodrich J.M., Calkins M.M., Caban-Martinez A.J., Stueckle T., Grant C., Calafat A.M., Nematollahi A., Jung A.M., Graber J.M., Jenkins T., Slitt A.L., Dewald A., Botelho J.C., Beitel S., Littau S., Gulotta J., Wallentine D., Hughes J., Popp C., Burgess J.L. Per- and polyfluoroalkyl substances (PFAS), epigenetic age, and DNA methylation: A cross-sectional study of firefighters. Epigenomics. 13(20): 1619-1636, 2021. PMCID: PMC8549684.

Goodrich J.M., Jung A.M., Furlong M.A., Beitel S., Littau S., Gulotta J., Wallentine D., Burgess J.L. Repeat measures of DNA methylation in an inception cohort of firefighters. Occup Environ Med. doi: 10.1136/oemed-2021-108153, 2022. PMID: 35332072.

Complete List of Published Work in MyBibliography:
https://www.ncbi.nlm.nih.gov/myncbi/jaclyn.goodrich.1/bibliography/public/ 

Email: [email protected] 
Office: 734-647-4564
Address: M6226 SPH II
1415 Washington Heights
Ann Arbor, MI 48109

For media inquiries: [email protected] 

Areas of Expertise: Child Health,  Environmental Health,  Genetics,  Global Public Health,  Maternal Health,  Occupational Health,  Precision Health,  Women’s Health