Faculty Profile
Hao Wang, MS, PhD, DABT
- Assistant Professor of Environmental Health Sciences
Dr. Wang has a broad background in biochemistry and toxicology, with a specific interest
in neurotoxicology research, including (1) studying the neurotoxicity of environmental
pollutants, (2) investigating the underlying mechanisms of environmental neurotoxicants,
(3) understanding how environmental toxicants contribute to the risk of neurological
diseases, and (4) developing prevention and intervention strategies to mitigate the
neurotoxicity of toxicants. His will primarily use the rodents as a vertebrate model,
combined with several cutting-edge technologies, including
metagenomic shotgun sequencing, single-cell RNA-sequencing analysis, and transgenic animals, to elucidate the cellular and molecular mechanisms of neurotoxicity for environmental pollutants, such as heavy metals, air pollution, pesticide, or multiple exposures.
metagenomic shotgun sequencing, single-cell RNA-sequencing analysis, and transgenic animals, to elucidate the cellular and molecular mechanisms of neurotoxicity for environmental pollutants, such as heavy metals, air pollution, pesticide, or multiple exposures.
- PhD, Environmental Toxicology, University of Washington, 2018
- MS, Biochemistry, Zhejiang University, 2012
- BS, Biology, Nanjing Normal University, 2009
Research Interests:
Neurotoxicology, Learning and memory deficits, Neurodegenerative diseases, Gut microbiome, The gut-brain axis, Adult neurogenesis, Neural stem cells
Research Projects:
K99/R00 grant from NIEHS: “Understanding the role of
the gut-brain axis in modulating Cadmium neurotoxicity”
Neurotoxicology, Learning and memory deficits, Neurodegenerative diseases, Gut microbiome, The gut-brain axis, Adult neurogenesis, Neural stem cells
Research Projects:
K99/R00 grant from NIEHS: “Understanding the role of
the gut-brain axis in modulating Cadmium neurotoxicity”
Wang H, Zhang L, Xia Z, Cui JY: Effects of chronic cadmium exposure on brain and liver transporters
and drug-metabolizing enzymes in male and female mice genetically predisposed to Alzheimer’s
disease. Drug Metabolism and Disposition
2022.
Zhang A, Matsushita MT, Zhang L, Wang H, Shi X, Gu H, Xia Z, Cui JY: Cadmium exposure modulates the gut-liver axis in an Alzheimer’s disease mouse model. Communications Biology 2021, 4(1), 1-16.
Wang H, Matsushita MT, Abel GM, Storm DR, Xia Z: Inducible and conditional activation of ERK5 MAP kinase rescues mice from cadmium-induced olfactory memory deficits. Neurotoxicology 2020, 81:127-136.
Wang H, Matsushita MT, Zhang L, Abel GM, Mommer BC, Huddy TF, Storm DR, Xia Z: Inducible and Conditional Stimulation of Adult Hippocampal Neurogenesis Rescues Cadmium-Induced Impairments of Adult Hippocampal Neurogenesis and Hippocampus-Dependent Memory in Mice. Toxicological Sciences 2020, 177:263-280.
Wang H, Abel, GM, Storm DR, Xia Z. Cadmium Exposure Impairs Adult Hippocampal Neurogenesis. Toxicological Sciences 2019, 171:501-514.
Wang H, Zhang L, Abel GM, Storm DR, Xia Z. Cadmium Exposure Impairs Cognition and Olfactory Memory in Male C57BL/6 Mice. Toxicological Sciences
2018, 161:87-102.
2022.
Zhang A, Matsushita MT, Zhang L, Wang H, Shi X, Gu H, Xia Z, Cui JY: Cadmium exposure modulates the gut-liver axis in an Alzheimer’s disease mouse model. Communications Biology 2021, 4(1), 1-16.
Wang H, Matsushita MT, Abel GM, Storm DR, Xia Z: Inducible and conditional activation of ERK5 MAP kinase rescues mice from cadmium-induced olfactory memory deficits. Neurotoxicology 2020, 81:127-136.
Wang H, Matsushita MT, Zhang L, Abel GM, Mommer BC, Huddy TF, Storm DR, Xia Z: Inducible and Conditional Stimulation of Adult Hippocampal Neurogenesis Rescues Cadmium-Induced Impairments of Adult Hippocampal Neurogenesis and Hippocampus-Dependent Memory in Mice. Toxicological Sciences 2020, 177:263-280.
Wang H, Abel, GM, Storm DR, Xia Z. Cadmium Exposure Impairs Adult Hippocampal Neurogenesis. Toxicological Sciences 2019, 171:501-514.
Wang H, Zhang L, Abel GM, Storm DR, Xia Z. Cadmium Exposure Impairs Cognition and Olfactory Memory in Male C57BL/6 Mice. Toxicological Sciences
2018, 161:87-102.
Email: [email protected]
Office Phone: 734-615-7005
Address: M6521 SPH II
1415 Washington Heights
Ann Arbor MI 48109
For media inquiries [email protected]
Office Phone: 734-615-7005
Address: M6521 SPH II
1415 Washington Heights
Ann Arbor MI 48109
For media inquiries [email protected]
Areas of Expertise: Brain Disorders, Chronic Disease, Environmental Health, Toxicology