Dr. Harris current interests include the role of oxidative stress and glutathione in mechanisms of developmental toxicology, redox-regulation of transcription factor activation, developmental gene expression, proliferation and differentiation, mechanisms of chemical toxicity in the developing limb and neural crest. He also teaches courses in developmental toxicology and biochemical and molecular toxicology.
- Ph.D., Toxicology, University of North Carolina, 1985
- M.S., Zoology, Brigham Young University, 1980
- B.S., Zoology, Brigham Young University, 1978
Research Interests & Projects
Current research is focused on mammalian developmental toxicology and attempts to elucidate biochemical mechanisms of teratogenesis. Particular emphasis is placed on investigations of how alterations in intracellular glutathione redox status produced by exposure to teratogenic chemicals misreguate transcription factor function and growth factor activity to produce dysmorphogenesis. Rodent and rabbit whole embryo culture systems and cell cultures are used for evaluation of the mechanisms of important embryotoxins/teratogens such as thalidomide, ethanol and PCBs.
Development of the next generation of rat whole embryo culture (WEC) prediction model
for the identification of development of developmental toxicants
Principal Investigator: Harris, C.
- Tetz, L.M., A. Cheng, C. Korte, R. Giese, P. Wang, C. Harris, and R. Loch-Caruso. (2013). Mono-2-ethylhexyl phthalate induced oxidative stress in human placebntal trophoblast cells: A proposed mechanism for phthalate-induced adverse pregnancy outcomes. Toxicology and Applied Pharmacology 47-54.
- Harris, C., D.L. Schuster, R. Roman Gomez, K.E. Sant, and J.M. Hansen (October, 2013). Inhibition of glutathione biosynthesis alters compartmental redox status and the thiol proteome in organogenesis-stage rat conceptuses. Free Radical Biology & Medicine 325-37.
- Sant K.S., Dolinoy D.C., Nahar M.S. and C. Harris (2013). Inhibition of proteolysis in histotrophic nutrtion pathways alters DNA methylation and one-carbon metabolism in the organogenesis-stage rat conceptus. Journal of Nutritional Biochemistry 1479-87.
- Hansen, J.M. and C. Harris (2012). Redox control of teratogenesis Reproductive Toxicology 165-79.
- Eistner, K. E. Granger, S. Wilson, N. Kumaradevan, M. Chew and C. Harris (2013). Schwannoma of the pulmonary artery. Heart Lung Circ 231-3.
- Ambroso, J.L. and C. Harris (2012). Assessment of Histiotrophic Nutrition using Fluorescent Probes. In C. Harris and J.M. Hansen (Ed.) Methods in Molecular Biology 407-23.