Faculty Profile

Sean  Harris, PhD

Sean Harris, PhD

Research Assistant Professor of Environmental Health Sciences
  • 6645 SPH I
  • 1415 Washington Heights
  • Ann Arbor, Michigan  48109-2029

Dr. Sean Harris is a Research Assistant Professor of Environmental Health Sciences in the School of Public Health. His research aims to advance our understanding of how environmental toxicants contribute to adverse pregnancy outcomes such as preterm birth and preeclampsia. Dr. Harris’s research uses a combination of approaches including transcriptomics, metabolomics, primary tissue models and computational/data mining methods to investigate molecular mechanisms of toxicant effects on the placenta and fetal membranes. Dr. Harris also investigates extracellular vesicles as a source for circulating biomarkers of toxicant effects on the placenta.

  • B.S., Biology, Western Michigan University, 2007
  • PhD., Environmental Toxicology, University of Washington, 2015

  • Harris SM*, Boldenow E*, Domino SE and Loch-Caruso R. (2020) Toxicant disruption of immune defenses: potential implications for fetal membranes and pregnancy. Frontiers in Physiology. 11:565 May, 2020 (*co-first authors) PMCID: PMC7272693
  • Harris SM, Jin Y, Loch-Caruso R, Padilla IY, Meeker J, Bakulski KM. (2020) Identification of environmental chemicals targeting miscarriage genes and pathways using the Comparative Toxicogenomics Database. Environmental Research. 184, May, 2020, 109259 PMCID: PMC7103533
  • Elkin E, Bridges D, Harris S, Loch-Caruso R. Exposure to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine causes compensatory changes to macronutrient utilization and energy metabolism in placental HTR-8/SVneo cells. Chemical Research in Toxicology. 2020 Jan 17 DOI: 10.1021/acs.chemrestox.9b00356 PMCID: PMC7299793
  • Elkin E*, Harris SM*, Su A, Loch-Caruso R. Placenta as a target of trichloroethylene toxicity. Environmental Science: Processes & Impacts. 2020, PMID: 32022077 DOI: 10.1039/c9em00537d (*co-first authors) PMCID: PMC7103546
  • Loch-Caruso R, Hassan I, Harris SM, Kumar A, Bjork F, Lash LH. Trichloroethylene exposure in mid-pregnancy decreased fetal weight and increased placental markers of oxidative stress in rats. Reprod Toxicol. 2019 Jan;83:38-45. PMCID: PMC6404769
  • Park HR*, Harris S*, Boldenow E, McEachin R, Sartor M, Chames M and Loch-Caruso R. Group B streptococcus activates transcriptomic pathways related to premature birth in human extraplacental membranes in vitro. Biology of Reproduction. 2018, 98(3):396-407 (*co-first authors) PMCID: PMC6248496
  • Elkin ER, Harris SM and Loch-Caruso R. Trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine induces lipid peroxidation-associated apoptosis via the intrinsic and extrinsic apoptosis pathways in a first-trimester placental cell line. Toxicol Appl Pharmacol. 2018, 338:30-42 PMCID: PMC5741094
  • Harris SM, Shubin SP, Wegner S, Van Ness K, Green F, Hong SW, Faustman EM. Presence of macrophages and inflammatory responses in an in vitro testicular co-culture model of male reproductive development enhances relevance to in vivo conditions. Toxicol. In Vitro. 2016, 36:210-5 PMCID: PMC5026229
  • Harris SM, Wegner S, Hong S, Faustman EM. Phthalate metabolism and kinetics in an in vitro model of testis development. Toxicol. In Vitro. 2016, 32:123-31 PMCID: PMC5193371
  • Harris SM, Hermsen S, Yu X, Hong SW, Faustman EM. Comparison of transcriptomic responses to phthalate ester exposure in an in vitro rat testes co-culture (TCS) model with responses observed in vivo. Reprod. Toxicol. 2015, 58:149-59 PMCID: PMC5166712