Dr. Karvonen-Gutierrez is an Assistant Professor of Epidemiology in the School of Public Health at the University of Michigan. Dr. Karvonen-Gutierrez’s research focuses on the impact of chronological aging, reproductive aging and obesity and their intersections, on the development and progression of chronic disease and musculoskeletal outcomes through the creation of a metabolically-dysfunctional and pro-inflammatory environment. To address her research agenda, Dr. Karvonen-Gutierrez pursues mechanistic and biologic hypotheses using both epidemiologic and clinical research designs leveraging her leadership in ongoing cohort studies as well as new data collection efforts.
Dr. Karvonen-Gutierrez received her PhD in Epidemiologic Science and MPH in Epidemiology from the University of Michigan. She is a National Institute of Aging Butler Williams Scholar and is on the Editorial Board at the Midlife Women’s Health journal. She has a K01 Mentored Research Scientist award from the National Institute of Aging to examine metabolomics and osteoarthritis. She is the Principal Investigator on the Michigan Bone Health and Metabolism Study and a co-Investigator on the Study of Women's Health Across the Nation.
- Ph.D., Epidemiologic Science, University of Michigan, 2012
- M.P.H., Epidemiology, University of Michigan, 2005
- B.A. , Biology, University of Northern Iowa, 2002
Research Interests & Projects
- Dr. Karvonen-Gutierrez is a faculty member of the Center for Midlife Science where she seeks to understand the importance of the midlife as a critical window of risk for the development of age-related diseases using two NIH-funded longitudinal cohorts now spanning 20 years of follow-up – the Study of Women’s Health Across the Nation (SWAN) and the Michigan Bone Health and Metabolism Study (MBHMS). Each study includes a broad range of data including musculoskeletal, endocrine, cardio-metabolic and health history data as well as bio-specimen repositories. Within the Center, Dr. Karvonen-Gutierrez provides leadership for the osteoarthritis, physical functioning and disability components of these two studies. In addition to this work, Dr. Karvonen-Gutierrez is the Principal Investigator of the Smoking and Knee Osteoarthritis Risk (SOAR) study which seeks to understand the seemingly protective impact of smoking on knee osteoarthritis. Her research program also includes a K01 award to use novel approaches including metabolomics for the identification of biomarkers for knee osteoarthritis.
- Jepsen, K.J., Kozminski, A., Bigelow, E.M., Schlecht, S.H., Goulet, R.W., Harlow, S.D., Cauley, J.A., Karvonen-Gutierrez, C. Femoral neck external size but not aBMD predicts structural and mass changes for women transitioning through menopause. J Bone Miner Res 2017;Jan 13.
- Chandrasekaran, N., Harlow, S., Moroi, S., Musch, D., Peng, Q., Karvonen-Gutierrez, C. Visual impairment at baseline is associated with future poor physical functioning among middle-aged women: The Study of Women's Health Across the Nation, Michigan Site. Maturitas 2017;96:33-38.
- Ylitalo, K.R., Karvonen-Gutierrez, C.A. Body mass index, falls, and injurious falls among U.S. adults: Findings from the 2014 Behavioral Risk Factor Surveillance System. Prev Med 2016;91:217-223.
- Karvonen-Gutierrez, C., Kim, C. Association of mid-life changes in body size, body composition and obesity status with the menopausal transition. Healthcare 2016;4(3)
- Jepsen, K.J., Bigelow, E.M.R., Ramcharan, M., Schlecht, S., Karvonen-Gutierrez, C. Moving toward a prevention strategy for osteoporosis by giving a voice to a silent disease. J Women’s Midlife Health 2016;2:3.
- Karvonen-Gutierrez, C.A., Park, S.K., Kim, C. Diabetes and menopause. Curr Diab Reports 2016;16(4):20.
- Ylitalo, K., Karvonen-Gutierrez, C.A., McClure, C., El Khoudary, S., Jackson, E.A., Sternfeld, B., Harlow, S.D. Is self-reported physical functioning associated with incident cardiometabolic abnormalities or the metabolic syndrome? Diabetes Metab Res Rev 2016;32(4):413-420.
- Karvonen-Gutierrez, C.A. The importance of disability as a health issue for mid-life women. Women’s Midlife Health 2015;1:10. doi: 10.1186/s40695-015-0011-x.
- Karvonen-Gutierrez, C.A., Zheng, H., Mancuso, P., Harlow, S.D. Higher leptin and adiponectin concentrations predict poorer performance-based physical functioning in mid-life women: the Michigan Study of Women’s Health Across the Nation. J Gerontol A Biol Sci Med Sci 2016;71(4):508-514.
- Karvonen-Gutierrez, C.A., Ylitalo, K.R. Prevalence and correlates of disability in a late middle-aged population of women. J Aging Health 2013;25:701-717
- Ylitalo, K.R., Karvonen-Gutierrez, C.A., Fitzgerald, N., Zheng, H., Sternfeld, B., El Khoudary, S.R., Harlow, S.D. Relationship of race/ethnicity, body mass index, and economic strain with longitudinal self-report of physical functioning: The Study of Women’s Health Across the Nation. Ann Epidemiol 2013;23(7):401-408.
- Karvonen-Gutierrez, C.A., Sowers, M.R., Heeringa, S.G. Sex dimorphism in the association of cardiometabolic characteristics and knee osteoarthritis among obese and non-obese adults: NHANES III. Osteoarthritis Cartilage 2012;20:614-621.
- Karvonen-Gutierrez, C.A., Harlow, S.D., Mancuso, P., Jacobson, J., Mendes de Leon, C.F., Nan, B. Leptin levels are associated with radiographic knee osteoarthritis among a cohort of mid-life women. Arthritis Care Res 2013;65:936-944.
- Karvonen-Gutierrez, C.A., Harlow, S.D., Jacobson, J., Mancuso, P., Jiang, Y. The relationship between longitudinal serum leptin and measures of magnetic resonance imaging-assessed knee joint damage in a population of mid-life women. Ann Rheum Dis 2014;73(5):883-889.
- Society for Epidemiologic Research (SER)
- Osteoarthritis Research Society International (OARSI)
- Gerontological Society of America (GSA)
- American Geriatrics Society (AGS)