Rudy J. Richardson, Sc.D., D.A.B.T.
- Professor of Toxicology, Environmental Health Sciences
- Dow Professor of Toxicology
- Associate Professor, Neurology
- Graduate Chair, Department of Environmental Health Sciences
- M6065 SPH II
- 1415 Washington Heights
- Ann Arbor, Michigan 48109-2029
Dr. Rudy J. Richardson received his BS (magna cum laude) in Chemistry from Wichita State University. Upon achieving PhD candidacy in Chemistry at Stony Brook, he transferred to Harvard, where he earned the ScM and ScD degrees in Physiology/Toxicology. After postdoctoral work in Neurochemistry at the Medical Research Council Toxicology Unit in Carshalton, England, he joined the University of Michigan as Assistant Professor of Toxicology. Apart from sabbatical leaves at Warner-Lambert/Parke-Davis (now Pfizer) in Ann Arbor and the University of Padua in Italy, Dr. Richardson has been based at Michigan, where he has risen through the ranks to full professor, ultimately being appointed as the Dow Professor of Toxicology. He also holds a joint appointment in the Neurology Department. Early in his career he became board-certified by the American Board of Toxicology (DABT), and he has renewed his certification every five years since. At various times, he has served as Director of the Toxicology Program, and currently he serves as Graduate Chair of the EHS Department. His research interests include computational toxicology, cheminformatics, biomarkers and biosensors of exposure and disease, mechanisms of neurodegenerative disease, chemistry and toxicology of organophosphorus and organic nitro compounds, interactions of toxicants with target macromolecules, and exposure assessment technology.
- Sc.D., Physiology/Toxicology, Harvard University, 1974
- Sc.M., Physiology/Toxicology, Harvard University, 1973
- PhD Candidate, Chemistry, Stony Brook University, 1970
- B.S., magna cum laude, Chemistry, Wichita State University, 1967
Research Interests & Projects
Computational toxicology, molecular modeling, ligand-receptor docking, receptor-ligand inverse docking, molecular dynamics simulations, drug discovery, biomarkers and biosensors of chemical exposures and biological consequences of chemical exposures, mechanisms of neurodegenerative disease, chemistry and toxicology of organophosphorus and organic nitro compounds.
- Novel Insights into Motor Neuron Disease
The goal of this research is to understand mechanisms of motor neuron diseases using genetic, molecular, biochemical, and toxicological approaches.
- 3D micro-GC for Indoor Air Contaminants
The goal of this project is to develop a 3D micro gas chromatograph for simultaneous identification and quantification of volatile and semi-volatile organic compounds (VOCs and semi-VOCs) in indoor environments.
- Hufnagel, R.B., Arno, G., Hein, N.D., Hersheson, J., Prasad, M., Anderson, Y., Krueger, L.A., Gregory, L.C., Stoetzel, C., Jaworek, T.J., Hull, S., Li, A., Plagnol, V., Willen, C.M., Morgan, T.M., Prows, C.A., Hegde, R.S., Riazuddin, S., Grabowski, G.A., Richardson, R.J., Dieterich, K., Huang, T., Revesz, T., Martinez-Barbera, J.P., Sisk, R.A., Jefferies, C., Houlden, H., Dattani, M.T., Fink, J.K., Dollfus, H., Moore, A.T., and Ahmed, Z.M. (2014). Neuropathy target esterase impairments cause Oliver-McFarlane and Laurence-Moon syndromes J. Med. Genet. (in press).
- Wijeyesakere, S.J., Richardson, R.J. and Stuckey, J.A. (2014). Crystal structure of patatin-17 in complex with aged and non-aged organophosphorus compounds. PLOS One, 9, e108245.
- Makhaeva, G.F., Rudakova, E.V., Hein, N.D., Serebryakova, O.G., Kovaleva, N.V., Boltneva, N.P., Fink, J.K., and Richardson, R.J. (2014). Further studies toward a mouse model for biochemical assessment of neuropathic potential of organophosphorus compounds J. Appl. Toxicol., 34, 1426-1435.
- Berent, S., Giordani, B., Albers, J.W., Garabrant, D.H., Cohen, S.S., Garrison, R.P., and Richardson, R.J. (2014). Effects of occupational exposure to chlorpyrifos on neuropsychological function: a prospective longitudinal study Neurotoxicology, 41, 44-53.
- Brott, D.A., Katein, A., Thomas, H., Lawton, M., Montgomery, R., Richardson, R.J., and Louden, C.S. (2014). Evaluation of von Willebrand factor and von Willebrand propeptide in models of vascular endothelial cell activation, perturbation and/or injury Toxicol. Pathol., 42, 672-683.
- Makhaeva, G.F., Lushchekina, S.V., Serebryakova, O.G., Aksinenko, A.Yu., Goreva, T.V., Richardson, R.J., and Martynov, I.V. (2013). Kinetics and mechanism of inhibition of serine esterases by fluorinated carbethoxy 1-aminophosphonates. Doklady Akademii Nauk (Biochemistry, Biophysics, Molecular Biology), 451, 203-206.
- Richardson, R.J., Hein, N.D., Wijeyesakere, S.J., Fink, J.K., and Makhaeva, G.F. (2013). Neuropathy target esterase (NTE): overview and future Chem. Biol. Interact., 203, 238-244.
- Makhaeva, G.F., Radchenko, E.V., Palyulin, V.A., Rudakova, E.V., Aksinenko, A.Y., Sokolov, V.B., Zefirov, N.S., and Richardson, R.J. (2013). Organophosphorus compound esterase profiles as predictors of therapeutic and toxic effects Chem. Biol. Interact., 203, 231-237.
- Makhaeva, G.F., Radchenko, E.V., Baskin, I.I., Palyulin, V.A., Richardson, R.J., and Zefirov, N.S. (2012). Combined QSAR studies of inhibitor properties of O-phosphorylated oximes toward serine esterases involved in neurotoxicity, drug metabolism, and Alzheimer’s disease. SAR QSAR Environ. Health, 23, 627-647.
- Wang, Y., Schneider, B., Sverina, E.A., Russ, K., Wijeyesakere, S.J., Fierke, C.A., Richardson, R.J., and Phillbert, M.A. (2012). Mixed inhibition of adenosine deaminase activity by 1,3- dinitrobenzene: a model for understanding cell-selective neurotoxicity in chemically induced energy deprivation syndromes in brain Toxicol. Sci., 125, 509-521.
- American Association for the Advancement of Science
- American Chemical Society
- Society of Toxicology