Faculty Profile

Randy Seeley

Randy J. Seeley, PhD

  • Henry King Ransom Endowed Professor, Surgery
  • Adjunct Professor, Internal Medicine
  • Adjunct Professor, Nutritional Sciences

    Dr. Randy Seeley is the Henry K. Ransom Endowed Professor of Surgery at the University of Michigan School of Medicine. Prior to that, Dr. Seeley was Professor of Medicine and held the Donald C. Harrison Endowed Chair at the University of Cincinnati College of Medicine where he also served as the Director of the Cincinnati Diabetes and Obesity Center (CDOC). His scientific work has focused on the actions of various peripheral hormones in the CNS that serve to regulate food intake, body weight and the levels of circulating fuels. His work has also focused on new treatment strategies for obesity and diabetes. He has published over 280 peer-reviewed articles including articles in Science, Nature, Nature Medicine, Nature Neuroscience, Science Translational Medicine, Cell Metabolism, The Journal of Clinical Investigation and the New England Journal of Medicine. Collectively, this work has been cited more than 20,000 times and Dr. Seeley has an H-index of 66. Dr. Seeley has received numerous awards including the 2009 Outstanding Scientific Achievement Award from the American Diabetes Association. In 2022, Dr Seeley received the American Association for the Advancement of Science Fellow. Dr. Seeley has also served on numerous review panels for the NIH and was Chair of the Integrative Physiology of Obesity and Diabetes review panel. He currently serves on the NIDDK Clinical Obesity Research Panel and on the Board of Reviewing Editors for Science.

    • NRSA Post-Doctoral Fellowship, University of Washington, 1993 - 1995
    • PhD in Psychology, University of Pennsylvania, 1993
    • MA in Psychology, University of Pennsylvania, 1990
    • BA in Psychology, Grinnell College, 1989

    Ryan KK, Tremarioli V, Clemmensen, C, Kovatcheva-Datchary, P, Myronovych, A, Wilson-Prez, HE, Sandoval DA, Kohli R, Backhed F. Seeley RJ. (2014) FXR is a molecular target for the effects of vertical sleeve gastrectomy. Nature. 509, 183-8. PMID: 24670636

    Ryan K.K., Li, B., Grayson, B.E., Matter, E.K., Woods, S.C. and Seeley, R.J. (2011). A role for central nervous system PPAR-y in the regulation of energy balance. Nature Medicine. 17, 623-626. PMID: 21532595

    Cota, D., Proulx, K., Smith, K.B., Kozma, S., Thomas, G., Woods, S.C. and Seeley, R.J. (2006). Hypothalamic mTOR regulates food intake. Science, 312, 927-930. PMID: 16690869

    Seeley, R.J., Yagaloff, K.A., Fisher, S.L., Burn, P., Thiele, T.E., van Dijk, G., Baskin, D.G. and Schwartz, M.W. (1997). Melanocortin receptors in leptin effects. Nature, 390, 349. PMID: 9389472

    Sisley S, Gutierrez-Aguilar R, Scott M, D'Alessio DA, Sandoval DA, Seeley RJ (2014). Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect. Journal of Clinical Investigation, 124:2456-63. PMID: 24762441

    Wortman, M.D., Clegg, D.J., D'Alessio, D.A., Woods, S.C. and Seeley R.J. (2003). C75 inhibits food intake by increasing CNS glucose metabolism. Nature Medicine, 9, 483-485. PMID: 12724740

    Grayson, BE, Schneider KM, Woods, SC, Seeley, RJ (2013). Reduced Intrauterine Growth Despite Improved Maternal Metabolic Parameters in a Rodent Model of Vertical Sleeve Gastrectomy, Science Translational Medicine, 5, 199ra112. PMID: 23966301

    Stefater, M.A., Prez-Tilve, D., Chambers, A.P., Wilson-Prez, H., Sandoval, D.A., Berger, J., Toure, M., Tschop, M., Woods, S.C. and Seeley, R.J., (2010). The effect of sleeve gastrectomy on leptin sensitivity in rats. Gastroenterology, 138,2426-36.PMID: 20226

    Reed, J.A., Clegg, D.J., Smith, K.B., Tolod-Richer, E.G., Matter, E.K., Picard, L. and Seeley, R.J. (2005). Granulocyte-Macrophage Colony-Stimulating Factor action in the CNS decreases food intake and body weight. Journal of Clinical Investigation, 115, 3035-3044. PMID: 16276414

    Strader, A.D., Reizes, O., Benoit, S.C., Woods, S.C. and Seeley, R.J. (2004). Mice lacking the syndecan-3 gene are resistant to dietary-induced obesity. Journal of Clinical Investigation, 114, 1354-1360. PMID: 15520868

    Email: seeleyrj@umich.edu
    Phone: 513-549-7411

    NCRC Building 26-343N
    2800 Plymouth Road
    University of Michigan
    Ann Arbor, MI 48109-2800

    Areas of Expertise: Nutrition