Faculty Profile

Randy J.  Seeley, PhD

Randy J. Seeley, PhD

Henry King Ransom Endowed Professor of Surgery

Adjunct Professor, Internal Medicine

Adjunct Professor, Nutritional Sciences

2800 Plymouth Road
NCRC Building 26-343N
University of Michigan
Ann Arbor, MI 48109-2800

Dr. Randy Seeley is the Henry K. Ransom Endowed Professor of Surgery at the University of Michigan School of Medicine.  Prior to that, Dr. Seeley was Professor of Medicine and held the Donald C. Harrison Endowed Chair at the University of Cincinnati College of Medicine where he also served as the Director of the Cincinnati Diabetes and Obesity Center (CDOC). His scientific work has focused on the actions of various peripheral hormones in the CNS that serve to regulate food intake, body weight and the levels of circulating fuels.  His work has also focused on new treatment strategies for obesity and diabetes.  He has published over 280 peer-reviewed articles including articles in Science, Nature, Nature Medicine, Nature Neuroscience, Science Translational Medicine, Cell Metabolism, The Journal of Clinical Investigation and the New England Journal of Medicine.  Collectively, this work has been cited more than 20,000 times and Dr. Seeley has an H-index of 66.  Dr. Seeley has received numerous awards including the 2009 Outstanding Scientific Achievement Award from the American Diabetes Association.  Dr. Seeley has also served on numerous review panels for the NIH and was Chair of the Integrative Physiology of Obesity and Diabetes review panel.  He currently serves on the NIDDK Clinical Obesity Research Panel and on the Board of Reviewing Editors for Science.  

  • B.A. in Psychology, Grinnell College, 1989
  • M.A. in Psychology, University of Pennsylvania, 1990
  • PhD in Psychology, University of Pennsylvania, 1993
  • NRSA Post-Doctoral Fellowship, University of Washington, 1993 - 1995

  • Ryan KK, Tremarioli V, Clemmensen, C, Kovatcheva-Datchary, P, Myronovych, A, Wilson-Pérez, HE, Sandoval DA, Kohli R, Bäckhed F. Seeley RJ. (2014) FXR is a molecular target for the effects of vertical sleeve gastrectomy. Nature. 509, 183-8.  PMID: 24670636

  • Ryan K.K., Li, B., Grayson, B.E., Matter, E.K., Woods, S.C. and Seeley, R.J. (2011). A role for central nervous system PPAR-γ in the regulation of energy balance.  Nature Medicine. 17, 623-626. PMID: 21532595

  • Cota, D., Proulx, K., Smith, K.B., Kozma, S., Thomas, G., Woods, S.C. and Seeley, R.J. (2006).  Hypothalamic mTOR regulates food intake.  Science, 312, 927-930.  PMID: 16690869

  • Seeley, R.J., Yagaloff, K.A., Fisher, S.L., Burn, P., Thiele, T.E., van Dijk, G., Baskin, D.G. and Schwartz, M.W. (1997). Melanocortin receptors in leptin effects. Nature, 390, 349.  PMID: 9389472

  • Sisley S, Gutierrez-Aguilar R, Scott M, D'Alessio DA, Sandoval DA, Seeley RJ (2014). Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect. Journal of Clinical Investigation, 124:2456-63.  PMID: 24762441

  • Wortman, M.D., Clegg, D.J., D'Alessio, D.A., Woods, S.C. and Seeley R.J. (2003).  C75 inhibits food intake by increasing CNS glucose metabolism. Nature Medicine, 9, 483-485.  PMID: 12724740

  •  Grayson, BE, Schneider KM, Woods, SC, Seeley, RJ (2013).  Reduced Intrauterine Growth Despite Improved Maternal Metabolic Parameters in a Rodent Model of Vertical Sleeve Gastrectomy, Science Translational Medicine, 5, 199ra112. PMID: 23966301

  • Stefater, M.A., Pérez-Tilve, D., Chambers, A.P., Wilson-Pérez, H., Sandoval, D.A., Berger, J., Toure, M., Tschöp, M., Woods, S.C. and Seeley, R.J., (2010). The effect of sleeve gastrectomy on leptin sensitivity in rats. Gastroenterology, 138,2426-36.PMID: 20226

  • Reed, J.A., Clegg, D.J., Smith, K.B., Tolod-Richer, E.G., Matter, E.K., Picard, L. and Seeley, R.J. (2005).  Granulocyte-Macrophage Colony-Stimulating Factor action in the CNS decreases food intake and body weight. Journal of Clinical Investigation, 115, 3035-3044.  PMID: 16276414

  • Strader, A.D., Reizes, O., Benoit, S.C., Woods, S.C. and Seeley, R.J. (2004).  Mice lacking the syndecan-3 gene are resistant to dietary-induced obesity.Journal of Clinical Investigation, 114, 1354-1360.   PMID: 15520868

  • American Diabetes Association
  • The Obesity Society
  • The Endocrine Society