Faculty Profile

Laurie  Svoboda, PhD

Laurie Svoboda, PhD

Research Assistant Professor, Environmental Health Sciences
  • M6232 SPH II
  • 1415 Washington Heights
  • Ann Arbor, MI  48109-2029

Dr. Laurie Svoboda is a Research Assistant Professor of Environmental Health Sciences at the University of Michigan School of Public Health. Dr. Svoboda completed her undergraduate degree in Chemical Engineering at Michigan State University and her doctoral degree in Toxicology at the University of Michigan. She then completed a postdoctoral fellowship at the University of Michigan, where she focused on understanding the epigenetic and metabolic drivers of pediatric soft tissue tumors.

Dr. Svoboda's research interests lie at the intersection of toxicology, cell metabolism, oxidative stress, and epigenetics. Her research is aimed at understanding the sex-specific effects of exposure to environmental toxicants during critical windows of development on cardiovascular health, with a focus on epigenetic mechanisms. She is also interested in understanding how maternal diet and nutrition modify the effects of developmental toxicant exposures. An additional area of interest is in the biochemical mechanisms underlying toxicant-induced epigenetic reprogramming. Dr. Svoboda co-leads the Dolinoy-Goodrich-Svoboda-Perera lab. 

EHS 796: Case Studies of Environmental Disasters: How Chemicals Cause Harm
EHS 869: Research Critiques and Scientific Communications in Environmental Health Sciences
EHS 660: Environmental Epigenetics and Public Health
 

  • PhD, Toxicology, University of Michigan, 2011
  • B.S., Chemical Engineering, Michigan State University, 2002

1. Liu S, Wang K, Svoboda LK, Rygiel C, Neier K, Jones T, Cavalcante R,  Colacino J, Dolinoy D, Sartor M. Perinatal DEHP exposure induces sex- and tissue- specific DNA methylation changes in both juvenile and adult mice. Environmental Epigenetics, 2021, doi: 10.1093/eep/dvab004.

2. Svoboda LK, Wang K, Jones TR, Colacino JA, Sartor MA, Dolinoy DC. Sex-Specific Alterations in Cardiac DNA Methylation in Adult Mice by Perinatal Lead Exposure. International Journal of Environmental Research and Public Health, 2021, doi: 10.3390/ijerph18020577.
3. Jiménez J, Apfelbaum A, Hawkins A, Svoboda LK, Kumar A, Ocadiz-Ruiz R, Garcia A, Haarer E, Nwosu Z, Bradin J, Purohit T, Chen D, Cierpicki T, Grembecka J, Lyssiotis C, Lawlor ER. EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing sarcoma. Molecular Cancer Research, 2021, doi: 10.1158/1541-7786.MCR-20-0679.

4. Svoboda LK, Neier KE, Wang K, Cavalcante RG, Rygiel CA, Tsai Z, Jones TR, Liu S, Goodrich JM, Lalancette C, Colacino J, Sartor MA, Dolinoy DC. Tissue and sex-specific programming of DNA methylation by perinatal lead exposure: implications for environmental epigenetics studies. Epigenetics, 2020, doi: 10.1080/15592294.2020.1841872.

5. Neier K, Montrose L, Chen K, Malloy M, Jones T, Svoboda LK, Harris C, Song P, Subramaniam P, Sartor M, Dolinoy D. Short- and long-term effects of perinatal phthalate exposures on metabolic pathways in the mouse liver. Environmental Epigenetics, 2020, doi: 10.1093/eep/dvaa017

6. Svoboda LK, Wang K, Cavalcante RG, Neier K, Colacino JA, Sartor MA, Dolinoy DC. Sex-Specific Programming of Cardiac DNA Methylation by Developmental Phthalate Exposure. Epigenetics Insights, 2020, 13, doi: 10.1177/2516865720939971.

7. Wang K, Liu S, Svoboda LK, Rygiel C, Neier K, Jones TR, Colacino JA, Dolinoy DC, Sartor MA. Tissue-and sex-specific DNA methylation changes in mice perinatally exposed to lead. Frontiers in Genetics, 2020, doi: 10.3389/fgene.2020.00840.

8. Malloy MA, Kochmanski JJ, Jones TR,  Colacino JA,  Goodrich JM, Dolinoy DC, Svoboda LK. Perinatal Bisphenol A Exposure and Reprogramming of Imprinted Gene Expression in the Adult Mouse Brain. Frontiers in Genetics, 2019, 10:951. doi: 10.3389/fgene.2019.00951.

9. Perera BPU, Svoboda LK*, Dolinoy DC. Genomic Tools for Environmental Epigenetics and Implications for Public Health. Current Opinion in Toxicology, 2019, 18:27–33.

10. Perera BPU, Faulk C, Svoboda LK, Goodrich JM, Dolinoy DC. The Role of Environmental Exposures and the Epigenome in Health and Disease. Environmental and Molecular Mutagenesis, 2019, doi: 10.1002/em.22311. Epub ahead of print.

11. Svoboda LK, Teh SS, Kerk S, Sud S, Zebolsky A, Treichel S, Thomas D, Van Noord RA, Halbrook C, Lee HJ, Kremer D, Zhang L, Magnuson B, Bankhead A, Ljungman M, Newman E, Cierpicki T, Grembecka J, Lyssiotis C, Lawlor ER. Menin regulates the serine biosynthetic pathway in Ewing sarcoma. Journal of Pathology, 2018, 245(3):324-336. PMID: 29672864. PMCID: PMC Journal – In Process.