Context-specific genetic regulation of chromatin architecture in complex traits
Online in Zoom
Online in Zoom

We study the effects of genetic variation on chromatin architecture and transcriptional regulation at single-cell resolution. Our research group uses an integrative approach of computational biology and functional genomics. The major goal of the lab is to generate mechanistic knowledge about how disease susceptibility is genetically encoded in the non-coding portion of the genome, with a focus on complex metabolic diseases. In this talk, I will present recent work on chromatin data QC, methods to detect functional signatures, single-nucleus resolution chromatin accessibility quantitative trait locus (caQTL) mapping, and colocalization with diabetes and related trait GWAS signals.

Context-specific genetic regulation of chromatin architecture in complex traits

Epidemiology Seminar Series with Stephen C.J. Parker, PhD, Associate Professor, Department of Computational Medicine & Bioinformatics, Department of Human Genetics, University of Michigan

icon to add this event to your google calendarMay 4, 2021
3:30 pm - 4:30 pm
Online in Zoom
Online URL: https://umich.zoom.us/j/97310514469
Contact Information: Sabrina Olsson, siclayto@umich.edu

We study the effects of genetic variation on chromatin architecture and transcriptional regulation at single-cell resolution. Our research group uses an integrative approach of computational biology and functional genomics. The major goal of the lab is to generate mechanistic knowledge about how disease susceptibility is genetically encoded in the non-coding portion of the genome, with a focus on complex metabolic diseases. In this talk, I will present recent work on chromatin data QC, methods to detect functional signatures, single-nucleus resolution chromatin accessibility quantitative trait locus (caQTL) mapping, and colocalization with diabetes and related trait GWAS signals.