Metabolomics: A promising tool to improve the understanding of the developmental origins of obesity and metabolic disease.
Metabolomics analyses to elucidate mechanisms in the development of obesity and insulin resistance
Description: Beginning at a younger age, there is an increase in the prevalence of obesity and insulin resistance; presenting the need to classify developmental influences that shape that risk of metabolic disease. One explanation is that during gestation, maternal nutrient availability causes structural and functional changes to fetal tissues, adapting to its external environmental to ensure survival. The aim of this dissertation is to use metabolomics to classify the metabolic environment during sensitive periods of early development to identify alterations in risk of adult obesity, insulin resistance, and additional metabolic diseases. Future studies aim to mitigate these developmental exposures to improve long-term metabolic health.