We study the effects of genetic variation on chromatin architecture and transcriptional regulation at single-cell resolution. Our research group uses an integrative approach of computational biology and functional genomics. The major goal of the lab is to generate mechanistic knowledge about how disease susceptibility is genetically encoded in the non-coding portion of the genome, with a focus on complex metabolic diseases. In this talk, I will present recent work on chromatin data QC, methods to detect functional signatures, single-nucleus resolution chromatin accessibility quantitative trait locus (caQTL) mapping, and colocalization with diabetes and related trait GWAS signals.
Sabrina Olsson, siclayto@umich.eduContext-specific genetic regulation of chromatin architecture in complex traits
Epidemiology Seminar Series with Stephen C.J. Parker, PhD, Associate Professor, Department of Computational Medicine & Bioinformatics, Department of Human Genetics, University of Michigan
May 4, 2021
3:30 pm - 4:30 pm
Online in Zoom
Contact Information: Sabrina Olsson, siclayto@umich.edu
We study the effects of genetic variation on chromatin architecture and transcriptional regulation at single-cell resolution. Our research group uses an integrative approach of computational biology and functional genomics. The major goal of the lab is to generate mechanistic knowledge about how disease susceptibility is genetically encoded in the non-coding portion of the genome, with a focus on complex metabolic diseases. In this talk, I will present recent work on chromatin data QC, methods to detect functional signatures, single-nucleus resolution chromatin accessibility quantitative trait locus (caQTL) mapping, and colocalization with diabetes and related trait GWAS signals.